The Controversial Role of Microglia in Malignant Gliomas

Figure 4

Glioma-associated microglia/macrophages (GAMs) are tumor supportive. Chemokines have a prominent role as they induce neoangiogenesis, activate matrix-metalloproteases (MMPs) and stroma remodeling, and direct tumor growth. Selected chemokines and immunosuppressive cytokines inhibit the anti-tumor immune response.