Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production after Allogeneic Stem Cells Transplantation
Table 2
Univariate analysis of factors associated with “differentiated phenotype” in CD8+ HCMV-specific T cells.
Parameter
All patients
Differentiated phenotype ()
Nondifferentiated phenotype ()
Univariate
OR (95% CI)
value
Posttransplant HCMV replication (, (%))
Yes
15 (57.7)
11 (73.3)
4 (26.6)
3.3 (0.6–17.2)
0.228
No
11 (42.3)
5 (45.4)
6 (54.5)
Donor age (, (%))
≥40
14 (53.8)
12 (85.7)
2 (14.3)
12 (1.4–85.2)
0.014
<40
12 (46.2)
4 (33.3)
8 (66.7)
Recipient age (, (%))
40
15 (57.7)
11 (73.3)
4 (26.6)
3.3 (0.6–17.2)
0.228
40
11 (42.3)
5 (45.4)
6 (54.5)
Donor HCMV serology (, (%))
Positive
14 (53.8)
11 (78.6)
3 (21.4)
5.1 (0.9–28.6)
0.105
Negative
12 (46.2)
5 (41.6)
7 (58.3)
Recipient HCMV serology (, (%))
Positive
23 (88.5)
16 (69.6)
7 (30.4)
15.4 (0.7–337.2)
0.110
Negative
3 (11.5)
0 (0)a
3 (100)
Stem cell source (, (%))
Peripheral blood
14 (53.8)
10 (71.4)
4 (28.6)
2.5 (0.5–12.6)
0.420
Bone marrow
12 (46.2)
6 (50)
6 (50)
OR: odds ratio. CI: confidence interval. “Differentiated phenotype” refers to patients with CD8+ T HCMV-specific cells, naive phenotype (CD45RA+CCR7+) ≤ 6.7% and CD28+ ≤ 30%. These cutoff values are the mean of all patients. values < 0.05 were considered statistically significant.
aWe have added 0.5 to categories with 0 individuals using EPIDAT 3.1 software.
