Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production after Allogeneic Stem Cells Transplantation

Table 3

Univariate analysis of factors associated with “INF-γ” production.

Parameter	All patients	QuantiFERON-HCMV assay		Univariate
		Reactive (𝑛=14)	Nonreactive (𝑛=8)	OR (95% CI)	𝑃 value
Post-SCT HCMV replication (𝑛, (%))
Yes	13 (59.1)	11 (84.6)	2 (15.4)	11 (1.4–85.2)	0.026
No	9 (40.9)	3 (33.3)	6 (66.7)
Donor age (𝑛, (%))
≥40	12 (54.5)	9 (75)	3 (25)	3 (0.5–16.2)	0.378
<40	10 (45.5)	5 (50)	5 (50)
Recipient age (𝑛, (%))
≥40	13 (59.1)	11 (84.6)	2 (15.4)	11 (1.4–85.2)	0.026
<40	9 (40.9)	3 (33.3)	6 (66.7)
Donor HCMV serology (𝑛, (%))
Positive	12 (54.5)	10 (83.3)	2 (16.7)	7.5 (1–54.1)	0.074
Negative	10 (45.5)	4 (40)	6 (60)
Recipient HCMV serology (𝑛, (%))
Positive	19 (86.4)	14 (73.7)	5 (26.3)	16.8 (0.8–418.6)	0.089
Negative	3 (13.6)	0 (0)^a	3 (100)
Stem cell source (𝑛, (%))
Peripheral blood	11 (50)	10 (90.9)	1 (9.1)	17.5 (1.6–191.9)	0.024
Bone marrow	11 (50)	4 (36.4)	7 (63.6)

OR: odds ratio. CI: confidence interval. “Reactive” patients have an INF-γ production higher than 0.2 IU/mL. “Nonreactive” patients have less than 0.2 IU/mL. 𝑃 values < 0.05 were considered statistically significant.
^aWe have added 0.5 to categories with 0 individuals using EPIDAT 3.1 software.