Lymphoid Progenitor Cells from Childhood Acute Lymphoblastic Leukemia Are Functionally Deficient and Express High Levels of the Transcriptional Repressor Gfi-1

Table 1

Reduced stem and progenitor cell content in ALL bone marrow.

	Control		ALL
	LTC-IC	CFC	LTC-IC	CFC
MNC	0.01073; (0.0098–0.0266); 1 LTC-IC/7760±2020	0.0740; (0.064–0.096); 1 CFC/1331±116	0.005425; (0.00475–0.01125); 1 LTC-IC/16124±3696	0.0010**; (0.0–0.010); 1 CFC/20494±4165
CD34^+		1.20; (1.16–1.54); 1 CFC/78±6		0.0**; (0.0–0.29); 1 CFC/422±77

Limiting dilution assays were conducted to determine the number of long term culture initiating cells (LTC-IC) and colony-forming cells (CFC) within mononuclear and CD34⁺ cell fractions from bone marrow (BM) acute lymphoblastic leukemia (ALL).
The results represent median (range) values and correspond to the percentage of LTC-IC and CFC within mononuclear or CD34⁺ cell fractions.
**Significantly lower (𝑃<0.01) than in control BM.