Investigation of Functional Activity of Cells in Granulomatous Inflammatory Lesions from Mice with Latent Tuberculous Infection in the New Ex Vivo Model

Table 1

The cellular composition of granulomas from spleens of mice after one (Gran/1) and two months (Gran/2) of being infected with BCG vaccine.

Granuloma cells	No. of granulomas with cells		No. of cells in
	Gran/1	Gran/2	Leukocyte infiltrations from mouse 6S/2	Gran/1	Gran/2
Macrophages	100.0	100.0	100.0	100.0	100.0
Dendritic cells	94.83±1.43	94.12±1.04	18.62±2.64	9.11±0.44	10.41±0.3
Lymphocytes	93.32±1.27	86.61±3.69	40.24±4.89	33.15±2.71	34.49±1.64
Fibroblasts	6.87±4.0^∗	19.59±3.52 *	—	5.64±1.17 **	9.95±0.65 **
Neutrophils	10.51±5.13	27.1±7.64	29.2±4.88	1.85±0.09	2.59±0.15
Eosinophils	26.84±6.89	14.27±3.26	—	7.5±0.87 ***	2.33±0.17 ***
Megakaryocytes	11.56±7.23	7.81±3.04	7.33±0.36	2.03±0.73	1.48±0.13
Langhans giant cells	3.1±2.62	2.32±1.52	—	1.5±0.12	0.89±0.04

Data is presented as mean percentage of the number of granulomas containing a particular cell type out of the total number of examined granulomas or a particular cell type, out of the macrophage population in the granulomas and the standard error of mean of Gran/1 (5 mice, 346 granulomas) and Gran/2 (20 mice, 857 granulomas). *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001.