PADI4 Haplotypes in Association with RA Mexican Patients, a New Prospect for Antigen Modulation

Table 4

Haplotype sequence and frequency of PADI4 gene SNPs (PADI4_89, PADI4_90, and PADI4_92) in healthy controls and RA patients.

Haplotypes	Condition	Frequencies		P	OR (95% CI)
		RA (𝑛=86)	HC (𝑛=98)
Haplotype 1 susceptibility GTG	Present	14	1	0.0002	18.9 (2.4–146.8)
	Absent	72	97
Haplotype 2 nonsusceptibility ACC	Present	5	6	1	0.95 (0.3–3.2)
	Absent	81	92
Haplotype 3 new susceptibility GTC	Present	42	28	0.006	2.4 (1.3–4.4)
	Absent	44	70
Haplotype 4 ACG	Present	43	39	0.18	1.5 (0.8–2.7)
	Absent	43	59
Haplotype 5 GCG	Present	1	10	0.011	0.1 (0.01–0.8)
	Absent	85	88
Haplotype 6 ATC	Present	3	8	0.22	0.4 (0.1–1.6)
	Absent	83	90
Haplotype 7 ATG	Present	6	6	1	1.1 (0.4–3.7)
	Absent	81	92
Haplotype 8 GCC	Present	1	4	0.4	0.3 (0.03–2.5)
	Absent	85	94

HC: healthy controls, RA: rheumatoid arthritis, and SNPs: single nucleotide polymorphisms.