TY - JOUR A2 - Clerici, Mario AU - Matowicka-Karna, Joanna AU - Kamocki, Zbigniew AU - PoliƄska, Beata AU - Osada, Joanna AU - Kemona, Halina PY - 2013 DA - 2013/03/10 TI - Platelets and Inflammatory Markers in Patients with Gastric Cancer SP - 401623 VL - 2013 AB - The aim of the study was to assess the contribution of platelets and inflammatory markers in gastric cancer. We studied 50 patients. Taking into consideration the advancement of gastric cancer, patients were divided into 3 groups. Group (E)—13 patients with early gastric cancer, group (A)—18 patients with regionally advanced cancer, and group (M)—19 patients with metastatic cancer. The determinations were performed twice prior to surgery and after surgery. In patients with gastric cancer, there is an increase in IL-6 and IL-23 compared with the healthy group. The highest values of IL-6 were obtained in early cancer (more than 8-fold increase), which seems to confirm the presence of acute inflammation. The lowest value of both of these cytokines was obtained in patients with metastatic cancer. In all patients, regardless of tumor stage, there was an increase in the concentration of CRP. An increase of PLT, higher proportion of the percentage of large platelets (LPLT), and increased mean platelet volume (MPV) were observed in the process of disease development. A positive correlation between MPV and LPLT and the accompanying decrease in the concentration of proinflammatory cytokines indicates the presence of an existing relationship between the platelet morphological parameters and the inflammation process in the development of gastric cancer. SN - 2314-8861 UR - https://doi.org/10.1155/2013/401623 DO - 10.1155/2013/401623 JF - Clinical and Developmental Immunology PB - Hindawi Publishing Corporation KW - ER -