Evidence of Stage- and Age-Related Heterogeneity of Non-HLA SNPs and Risk of Islet Autoimmunity and Type 1 Diabetes: The Diabetes Autoimmunity Study in the Young

Figure 1

Association between SNP rs10517086 and development of IA modeled using a restricted cubic spline. The hazard ratio at different ages is represented by the solid line and the 95% confidence intervals are represented by the dotted lines. Hazard ratios and 95% confidence intervals are shown at 9 months, 2 years, 4 years, and 6 years (denoted with short vertical lines) illustrating the increased risk of developing IA in the younger ages, but not in older ages.