|CI: confidence interval; DAISY: Diabetes Autoimmunity Study in the Young; HLA: human leukocyte antigen; HR: hazard ratio; IA: islet autoimmunity; MAF: minor allele frequency; T1D: type 1 diabetes.|
aMinor allele frequency (MAF) calculated for children negative for IA.
bAdjusted for HLA-DR3/4, DQB1*0302 genotype and first degree relative with T1D. TLR8 (rs5979785) is additionally adjusted for sex because it is on the X chromosome.
cAdjusted for HLA-DR3/4, DQB1*0302 genotype, first degree relative with T1D, and age at first antibody positive visit. TLR8 (rs5979785) is additionally adjusted for sex because it is on the X chromosome.
dSNP analyzed additively with HR representing increase in risk for each additional minor allele.
eSNP analyzed dichotomously with HR representing increase in risk for at least one minor allele.
*SNP rs10517086 did not meet the assumptions of proportional hazards in the development of IA analysis and therefore was modeled using a restricted cubic spline (Figure 1).