Journal of Immunology Research / 2013 / Article / Tab 2

Clinical Study

Evidence of Stage- and Age-Related Heterogeneity of Non-HLA SNPs and Risk of Islet Autoimmunity and Type 1 Diabetes: The Diabetes Autoimmunity Study in the Young

Table 2

Association between non-HLA T1D candidate SNPs and development of IA, progression from IA to T1D, and development of T1D adjusted for HLA-DR3/4, DQB1*0302 genotype and first degree relative with T1D.

SNPMinor alleleDevelopment of IA ( ) Progression from IA to T1D
  ( )
Development of T1D
  ( )
MAFaAdjusted HRb and 95% CI valueAdjusted HRc and 95% CI valueAdjusted HRb and 95% CI value

C1QTNF6 (rs229541)A0.441.57 (1.20, 2.05 0.0011.13 (0.75, 1.71)d0.561.95 (1.33, 2.87 0.001
C6orf173 (rs9388489) G0.461.15 (0.88, 1.51)d0.310.87 (0.61, 1.24)d0.441.03 (0.69, 1.54)d0.87
C14orf181 (rs1465788) T0.280.97 (0.73, 1.27)d0.801.09 (0.62, 1.92)e0.770.70 (0.40, 1.23)e0.21
IL2 (rs2069762)C0.291.08 (0.82, 1.43)d0.581.22 (0.79, 1.87)d0.381.20 (0.79, 1.83)d0.40
IL2 (rs4505848)G0.351.04 (0.80, 1.34)d0.780.93 (0.67, 1.28)d0.651.18 (0.82, 1.70)d0.37
IL2RA (rs12722563)A0.120.90 (0.58, 1.41)e0.650.52 (0.17, 1.57)e0.250.43 (0.17, 1.08)e0.07
IL2RA (rs2104286)C0.270.85 (0.63, 1.15)d0.281.26 (0.70, 2.27)e0.440.77 (0.43, 1.38)e0.38
IL7R (rs6897932)T0.280.93 (0.68, 1.28)d0.660.86 (0.49, 1.53)e0.610.88 (0.50, 1.55)e0.65
PRKCQ (rs947474) G0.171.19 (0.80, 1.77)e0.400.76 (0.41, 1.42)e0.390.87 (0.47, 1.64)e0.67
SKAP2 (rs7804356) C0.250.90 (0.66, 1.22)d0.491.54 (0.83, 2.85)e0.171.01 (0.57, 1.78)e0.99
SMARCE1 (rs7221109)T0.350.94 (0.72, 1.22)d0.630.94 (0.57, 1.57)d0.820.73 (0.45, 1.20)d0.21
TLR8 (rs5979785)C0.200.82 (0.64, 1.05)d0.110.84 (0.61, 1.16)d0.290.86 (0.60, 1.24)d0.43
UBASH3A (rs3788013)A0.441.19 (0.89, 1.59)d0.251.03 (0.72, 1.48)d0.861.63 (1.04, 2.54 0.03
rs10517086A0.30**1.36 (0.77, 2.41)e0.302.03 (1.35, 3.03 0.001

CI: confidence interval; DAISY: Diabetes Autoimmunity Study in the Young; HLA: human leukocyte antigen; HR: hazard ratio; IA: islet autoimmunity; MAF: minor allele frequency; T1D: type 1 diabetes.
aMinor allele frequency (MAF) calculated for children negative for IA.
bAdjusted for HLA-DR3/4, DQB1*0302 genotype and first degree relative with T1D. TLR8 (rs5979785) is additionally adjusted for sex because it is on the X chromosome.
cAdjusted for HLA-DR3/4, DQB1*0302 genotype, first degree relative with T1D, and age at first antibody positive visit. TLR8 (rs5979785) is additionally adjusted for sex because it is on the X chromosome.
dSNP analyzed additively with HR representing increase in risk for each additional minor allele.
eSNP analyzed dichotomously with HR representing increase in risk for at least one minor allele.
*SNP rs10517086 did not meet the assumptions of proportional hazards in the development of IA analysis and therefore was modeled using a restricted cubic spline (Figure 1).

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