Immunogenetic Study in Chinese Population with Ankylosing Spondylitis: Are There Specific Genes Recently Disclosed?

Table 1

Genes/gene regions definitely associated with AS in Chinese population.

Chromosome location	Putative genes/candidate genes	SNP	Reference allele	Replicated or not	P value
6p21	HLA-B	rs13202464	G	Yes	<5.0 × 10^−324
5q15	ERAP1	rs27434	A	Yes	6.68 × 10^−4
5q15	ERAP1	rs30187	T	Yes	6.71 × 10^−4
1p31	IL-23R	rs11209026	G	Yes	2.3 × 10^−17
5q33	IL12B	rs3212227	C	Yes	/
12p13	TNFRSF1A	rs4149577	A	Yes	8.2 × 10^−4
1q21	FCRL4	rs2777963	T	No	/
1q23	FCGR2B	rs10917661	C	No	/
12q24.31	ORAI1	rs7135617	T	No	0.008
12q24.31	ORAI1	rs712853	C	No	0.002
5q14.3	HAPLN1-EDIL3	rs4552569	C	No	8.77 × 10^−10
12q12	ANO6	rs17095830	G	No	1.63 × 10^−8
2p15	Unknown	rs10865331	A	Yes	1.98 × 10^−8
6q21	Unknown	rs13210693	A	No	9.31 × 10^−7

SNP: single nucleotide polymorphisms; HLA: human leukocyte antigen; ERAP1: endoplasmic reticulum aminopeptidase 1; IL-23R: interleukin-23 receptor; IL12B: interleukin-12B; TNFRSF1A: tumor necrosis factor receptor superfamily, member 1A; FCRL4: Fc receptor-like molecule 4; FCGR2B: Fc gamma receptor IIB; ORAI1: ORAI calcium release-activated calcium modulator 1; HAPLN1: hyaluronan and proteoglycan link protein 1; EDIL3: EGF-like repeats and discoidin I-like domains 3; ANO6: anoctamin 6.