Osteoclasts and CD8 T Cells Form a Negative Feedback Loop That Contributes to Homeostasis of Both the Skeletal and Immune Systems
Figure 1
Tonic and reactive regulatory motifs: (a) the tonic regulatory motif maintains homeostasis by adjusting the concentration of a suppressor [S], which sets the upper bound of the activating threshold. In some cases, basal levels of an activator [R] establish the lower bound. (b) The reactive regulatory motif maintains homeostasis typically through a negative feedback loop. Negative feedback produces spiked activation and oscillations under some circumstances.
