Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127− T-Cells in Children with Long-Lasting Type 1 Diabetes

Table 1

General characteristics of study groups. Data are presented as mean ± standard deviation or median (interquartile range) for normally and nonnormally distributed data, respectively.

	Study group	Control group	P value
Number of patients	33	52
Gender (boys/girls), n (%)	16 (48)/17 (52)	28 (54)/24 (46)
Age (yrs)	14.3±2.6	14.6±2.7	0.55
Height (m)	1.6±0.1	1.6±0.1	0.88
Body mass (kg)	59.5±13.7	54.9±13.4	0.12
Body mass index (kg/m^2)	22.1±3.3	20.2±2.8	<0.001
SDS-BMI	1.0±1.0	0.3±0.9	0.01
Age of onset (yrs)	7.3±3.2
Disease duration (yrs)	7.0±2.8
HbA1c level	8.8±1.8% (72.7±19.7 mmol/mol)
HbA1c level (mean from last 6 months)	8.8±1.5% (72.7±16.4 mmol/mol)
Systolic blood pressure (mmHg)	115±9	115±11	0.86
Diastolic blood pressure (mmHg)	70±6	68±9	0.45
Total cholesterol (mmol/L)	4.6±0.7	4.1±0.6	0.01
LDL-cholesterol (mmol/L)	2.4±0.6	2.3±0.5	0.3
HDL-cholesterol (mmol/L)	1.6±0.3	1.3±0.3	<0.001
Triglycerides (mmol/L)	0.7 (0.6–1)	0.8 (0.5–1.1)	0.8
IMT (mm)	0.49±0.05	0.43±0.06	<0.001
FMD (%)	7.1±5.1	10.8±4	0.007