Role of Toll-Like Receptor 4 on Lupus Lung Injury and Atherosclerosis in LPS-Challenge ApoE^−/− Mice

Figure 2

Haemorrhage pulmonary capillaritis in lung of the ApoE^−/− and wild-type mice. Sporadic hemosiderin-laden macrophages were highlighted by Perl's staining for iron (stained blue). Enhanced haemorrhage pulmonary capillaritis was found in LPS-primed ApoE^−/− mice by HE ((a)–(f), 200x) and Perl's staining ((g)–(l), 400x).

(a) Wild-type NS

(b) Wild-type LPS

(c) Wild-type LPS + TAK-242

(d) ApoE^−/− NS

(e) ApoE^−/− LPS

(f) ApoE^−/− LPS + TAK-242

(g) Wild-type NS

(h) Wild-type LPS

(i) Wild-type LPS + TAK-242

(j) ApoE^−/− NS

(k) ApoE^−/− LPS

(l) ApoE^−/− LPS + TAK-242