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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 482691, 7 pages
Clinical Study

Clinical Differences between Men and Women with Psoriatic Arthritis: Relevance of the Analysis of Genes and Polymorphisms in the Major Histocompatibility Complex Region and of the Age at Onset of Psoriasis

1Rheumatology Department, Hospital Universitario Central de Asturias (HUCA), C/Celestino Villamil s/n, Oviedo, 33006 Asturias, Spain
2Psoriasis Unit, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain
3Dermatology Department, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain
4Clinical Epidemiology Unit, BIODONOSTIA, San Sebastian, Basque Country, Spain
5Department of Functional Biology, Oviedo University School of Medicine, Oviedo, Asturias, Spain
6Immunology Service, HUCA, Oviedo, Asturias, Spain

Received 16 September 2012; Revised 17 March 2013; Accepted 28 March 2013

Academic Editor: Chung Tei Chou

Copyright © 2013 Rubén Queiro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It has been shown that males with spondyloarthritis tend to suffer from more severe spinal disease while females are more likely to have peripheral joint involvement. Nevertheless, gender-related differences have not been thoroughly explored in psoriatic arthritis (PsA). In PsA, males accumulate more peripheral and axial joint damage compared to women. However, it is not clear whether these findings are secondary to differences in occupational physical activity, hormonal changes, or other factors. The present study analyzed the differences in clinical expression of PsA between men and women. We have also evaluated the possible existence of gender-linked differences in the distribution of genes and polymorphisms within the major histocompatibility complex and whether patients’ age at the onset of psoriasis established any differences in these aspects. Women suffered more polyarthritis, greater functional impairment, and a larger number of swollen joints during followup. We appreciated a differential expression of certain MHC genes according to gender and age at onset of psoriasis. Our results point to the need to include patient’s age at the onset of psoriasis and gender as key stratification elements in future studies of genetic associations in PsA.