Heart Allograft Tolerance Induced and Maintained by Vascularized Hind-Limb Transplant in Rats

Figure 4

ELISPOT showed a significantly reduced frequency of BN-reactive IFN-γ secreting T cells in the spleen of tolerized LEW recipients, compared with that of rejecting LEW recipients (933.3±90.76 versus 440.1±35.17, 𝑛=3, 𝑃=0.0071). In contrast, rejecting and tolerant LEW had similar frequency of ACI-reactive splenic T cells (151.1±17.78 versus 191.1±32.74, 𝑛=3, 𝑃=0.3434).