Effects of Rapamycin Combined with Low Dose Prednisone in Patients with Chronic Immune Thrombocytopenia

Figure 2

The suppressive activity of Treg cells before and after the treatment in the experimental group; (a) the suppressive ability for CD4⁺ T cells; (b) the suppressive ability for CD8⁺ T cells. The pretreatment baseline levels of Treg cells suppression was significantly lower for CD4⁺ cells and CD8⁺ cells than those in the healthy controls (6.87±1.24% versus 11.28±1.60%, 𝑃<0.001; 6.86±0.95% versus 10.93±2.04%, 𝑃<0.005). Following the rapamycin treatment, the suppression for CD4⁺ cells (9.15±0.64%, 𝑃=0.007) and CD8⁺ cells (8.89±0.73%, 𝑃=0.001) was stronger than that before the treatment.

(a)

(b)