Notch Signaling and T-Helper Cells in EAE/MS

Table 3

Notch and animal models of immune mediated diseases.

Animal model	Method	Results	References
Allergic conjunctivitis	Anti-Dll4	↑Disease, ↑Th2	Fukushima et al., 2008 [40]
Allergic asthma	Anti-Dll4	↑Disease, ↓Treg function	Huang et al., 2009 [41]
Allergic airway response	Anti-Dll4	↑Disease, ↑Th2	Jang et al., 2010 [42]
Autoimmune uveoretinitis	Anti-Dll4	↑Disease, ↓Th17	Ishida et al., 2011 [43]
T1D	Anti-Dll4	↓Disease, ↑Treg	Billiard et al., 2012 [14]
Graft versus host disease	Anti-Dll4	↑Survival, ↓Th1, and ↓Th17	Mochizuki et al., 2013 [44]
Allogeneic cardiac transplant	Anti-Dll1	↑Survival, ↓Th1, and ↓cytotoxic T cell	Riella et al., 2011 [45]
Airway hyperresponsiveness	Jagged1-Fc	↑Disease, ↑Th2	Okamoto et al., 2009 [46]
Murine cardiac transplant	Anti-Jagged2 signaling Ab	↓Survival, ↑IL-2, and ↑IL-6	Riella et al., 2013 [47]