Journal of Immunology Research / 2013 / Article / Tab 3

Research Article

Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma

Table 3

Correlation of HIF-2α, TWIST, and CXCR4 protein expression with clinicopathological parameters in 129 PTCs.

CharacteristicsCase ( )HIF-2αTWISTCXCR4
LowHigh valueLowHigh valueLowHigh value

Tissue type
 Normal thyroid tissue118118011801180
 Nodular hyperplasia61610610610
 PTC1296564<0.001a
<0.001b
7356<0.0015871<0.001a
 <0.001b
Classic PTC8040400.98044360.96339410.672
 Follicular variant of PTC211110129912
 Tall cell variant of PTC157896510
 Oncocytic variant of PTC13768558
Age (years)
 ≤456935340.93543260.15933360.483
60303030302535
Gender
 Male3216160.96020120.43713190.570
 Female97494853444552
Tumor size (cm)
 ≤2.38345380.24351320.13540430.322
46202622241828
TNM stage
 I-II6935340.93541280.48731380.993
 III-IV60303032282733
Lymph node metastasis
 Absent614615<0.0015011<0.0014021<0.001
 Present68194923451850

values derived using chi-square test to compare the expression of HIF-2α, TWIST, and CXCR4 between subgroups defined by each clinicopathological parameter; asignificant difference between PTCs and normal thyroid tissues; bsignificant difference between PTCs and nodular hyperplasia. significant difference.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.