Journal of Immunology Research / 2013 / Article / Tab 3

Research Article

Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma

Table 3

Correlation of HIF-2α, TWIST, and CXCR4 protein expression with clinicopathological parameters in 129 PTCs.

CharacteristicsCase ( )HIF-2αTWISTCXCR4
LowHigh valueLowHigh valueLowHigh value

Tissue type
 Normal thyroid tissue118118011801180
 Nodular hyperplasia61610610610
Classic PTC8040400.98044360.96339410.672
 Follicular variant of PTC211110129912
 Tall cell variant of PTC157896510
 Oncocytic variant of PTC13768558
Age (years)
Tumor size (cm)
TNM stage
Lymph node metastasis

values derived using chi-square test to compare the expression of HIF-2α, TWIST, and CXCR4 between subgroups defined by each clinicopathological parameter; asignificant difference between PTCs and normal thyroid tissues; bsignificant difference between PTCs and nodular hyperplasia. significant difference.

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