Selection of Conserved Epitopes from Hepatitis C Virus for Pan-Populational Stimulation of T-Cell Responses

Figure 2

HCV polyprotein with variable positions masked. The figure shows the amino acid sequence HCV-polyprotein (protein id; AAA45676.1) with residues positions with a sequence variability >0.5 masked (shown as dots). We computed sequence variability from a multiple sequence alignment of HCV polyproteins using Shannon entropy, 𝐻, and masked the variable sites on the reference sequence as detailed in Section 2. The mature proteins that arise upon HCV-polyprotein processing are indicated.