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Clinical and Developmental Immunology
Volume 2013, Article ID 631408, 12 pages
Review Article

Enteropathic Spondyloarthritis: From Diagnosis to Treatment

1Rheumatology Research Unit, University Federico II, 80131 Naples, Italy
2Department of Clinical and Experimental Medicine, University Federico II, 80131 Naples, Italy
3Regional Reference Center for Coagulation Disorders, University Federico II, 80131 Naples, Italy
4Complex Operating Unit of Gastroenterology, AORN “A.Cardarelli,” Via Sergio Pansini 5, 80131 Naples, Italy
5Gastroenterology Research Unit, University Federico II, 80131 Naples, Italy

Received 19 October 2012; Accepted 25 March 2013

Academic Editor: Chung Tei Chou

Copyright © 2013 Rosario Peluso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Enteropathic arthritis (EA) is a spondyloarthritis (SpA) which occurs in patients with inflammatory bowel diseases (IBDs) and other gastrointestinal diseases. Diagnosis is generally established on the medical history and physical examination. It was, generally, made according to the European Spondyloarthropathy Study Group (ESSG) criteria. Rheumatic manifestations are the most frequent extraintestinal findings of IBD with a prevalence between 17% and 39%, and IBD is associated, less frequently, with other rheumatic disease such as rheumatoid arthritis, Sjogren syndrome, Takayasu arteritis, and fibromyalgia. Although the pathogenesis of EA has not been plainly clarified, the most popular theory supposes that joint inflammation occurs in genetically predisposed subjects with bacterial gut infections, provided an important evidence for a possible relationship between inflammation of the gut mucosa and arthritis. The management of patients with EA requires an active cooperation between the gastroenterologist and rheumatologist.