Targeting BCL2 Family in Human Myeloid Dendritic Cells: A Challenge to Cure Diseases with Chronic Inflammations Associated with Bone Loss

Figure 2

Classification of the BCL2 family into three subfamilies of BCL2-related proteins. The four BCL2 homology (BH) domains are the most highly conserved among BCL2 family. The prosurvival proteins contain four α-helix BH domains (BH1-4). BH1-3 domains of prosurvival proteins form a hydrophobic cleft that binds proapoptotic proteins through their hydrophobic BH3 domains.The multidomain proapoptotic proteins have BH1-3 domains, while the proapoptotic BH3-only proteins share only the BH3 domain with the other BCL2-related proteins. Most members have a carboxy-terminal hydrophobic transmembrane (TM) domain, with the exceptions of many of the BH3-only proteins and probably BCL2A1.