Clinical Phenotypes of Patients with Anti-DFS70/LEDGF Antibodies in a Routine ANA Referral Cohort

Figure 1

Correlation between dense fine speckled (DFS) pattern by indirect immunofluorescence (IIF) and anti-DFS70 antibodies measured by chemiluminescent immunoassay (CIA). (a) Correlation between the anti-DFS antibody titer by IIF and by QUANTA Flash DFS70. Excellent correlation between the anti-DFS antibody titers by IIF and by QUANTA Flash DFS70 was found using the samples showing the DFS speckled pattern (𝑛=100). Number and percent of the anti-DFS70 antibody positive samples are shown per titer group (cut-off = 20 CU). (b) Receiver operating characteristics (ROC) analysis comparing samples with DFS (𝑛=100) and other IIF ANA patterns (𝑛=100) by means of anti-DFS70 antibodies. Excellent discrimination between samples with DFS pattern and other patterns was observed as underlined by an area under the curve value of 0.981 (95% CI 0.960–1.000).

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