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Clinical and Developmental Immunology
Volume 2013, Article ID 712561, 11 pages
Research Article

Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7

1Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine (SJTUSM), 225 South Chongqing Road, Shanghai 200025, China
2Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated First People’s Hospital, 100 Haining Road, Shanghai 200080, China
3Department of Endocrinology and Metabolism, Ruijin Hospital, SJTUSM, 197 Ruijin 2nd Road, Shanghai 200025, China
4Shanghai Institute of Immunology, Institutes of Medical Sciences, SJTUSM, 280 South Chongqing Road, Shanghai 200025, China
5Department of Endocrinology and Metabolism, The First Affiliated Hospital of Bengbu Medical College and Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Bengbu Medical College, 287 Changhuai Road, Bengbu 233004, China
6Cancer Hospital, HeFei Institutes of Physical Science, Chinese Academy of Science, 350 Shushan Lake Road, HeFei 230031, China

Received 9 August 2013; Accepted 12 October 2013

Academic Editor: Marco Antonio Velasco-Velázquez

Copyright © 2013 Shipeng Dang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure: LMW-HA has no effect on TLR4 negative K1 cell proliferation and migration. To investigate if LMW-HA promotes proliferation and migration of W3 cells via TLR4, TLR4 negative K1 cells was stimulated with LMW-HA, and the data showed that LMW-HA did not promote the proliferation and migration of K1 cells, moreover it also did not upregulate CXCR7 expression on K1 cells.

  1. Supplementary Figure