Altered Sympathetic-to-Immune Cell Signaling via β2-Adrenergic Receptors in Adjuvant Arthritis
The effects of twice-daily treatment with terbutaline (Terb) (total of 1200 μg/day i.p.) or vehicle (Veh) in arthritic rats from D12–D28 post-CFA challenge on ex vivo IFN-γ secretion by splenocytes (a), and draining lymph node (DLN) cells (b). Terb had no effect on IFN-γ secretion by cultured spleen cells (a), but significantly increased (*) IFN-γ production by DLN cells. Data are expressed as means ± SEM (/group) and analyzed using a Student’s -test.
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