Synergy between Vitamin D₃ and Toll-Like Receptor Agonists Regulates Human Dendritic Cell Response during Maturation

Figure 2

Vitamin D₃ is necessary for LPS-induced secretion of IL-6, IL-8, and IL-10. DC were stimulated with 0, 20, or 100 nM of vitamin D₃ (vitamin D) and 10-fold dilutions of LPS (from 100 to 0.01 ng/mL). Cell-culture supernatants were assessed for IL-6 (a), IL-8 (b), IL-10 (c), and IL-12 (d) by ELISA. Experiment is representative of at least two independent experiments.

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