Journal of Immunology Research / 2013 / Article / Fig 5

Research Article

Immunological Demyelination Triggers Macrophage/Microglial Cells Activation without Inducing Astrogliosis

Figure 5

Immunological demyelination attenuates the induction of distal reactive. (a) Schematic drawing of different experimental groups and where analysis of white pixel and GFAP-positive cell counts were conducted. (b) GFAP-stained serial section to (c). The injury site is surrounded by wide spread astrogliosis in the gray and the white matter. (c) Eriochrome cyanine R-stained transverse section showing the injury site (I). (d) GFAP-stained serial section to (e). Astrogliosis is still evident 1 mm rostral the injury epicenter. (f) GFAP-stained serial section to (g). (f) Astrogliosis is markedly reduced within the region of demyelination (*, hatched line). (e) Eriochrome cyanine R-stained transverse section showing the region of demyelination 1 mm rostral the injury epicenter. (j) Whereas there is a significant increase in % of GFAP staining 1 mm rostral to the injury epicenter, regions of immunological demyelination showed a similar percentage of GFAP staining compared to normal white matter. (k) The numbers of GFAP-positive cells within regions of immunological demyelination either alone or 1 mm rostral to the injury epicenter are similar compared to those of the normal dorsal column. **: . Scale bars: (b)-(c) 100 μm; (d)–(i) 50 μm.
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