Replication of British Rheumatoid Arthritis Susceptibility Loci in Two Unrelated Chinese Population Groups
Table 3
Allele and genotype frequencies of SNPs in test cohort.
SNP
Chromosome
Gene
Allele
Allele analysis
Genotype
Genotype analysis
Controls number (%)
Cases number (%)
OR (95% CI)
Controls number (%)
Cases number (%)
OR (95% CI)
rs6457617
6q
MHC
T
218 (59.2)
263 (71.1)
1 (reference)
—
TT
68 (37.0)
97 (52.4)
1 (reference)
—
C
150 (40.8)
107 (28.9)
0.59 (0.44–0.80)
0.001
CT
82 (44.6)
69 (37.3)
0.59 (0.38–0.92)
0.02
CC
34 (18.5)
19 (10.3)
0.39 (0.21–0.74)
0.004
rs11761231
7q32
Unknown
T
287 (75.9)
290 (76.7)
1 (reference)
—
TT
108 (57.1)
112 (59.3)
1 (reference)
—
C
91 (24.1)
88 (23.3)
0.96 (0.68–1.34)
0.80
CT
71 (37.6)
66 (34.9)
0.90 (0.59–1.37)
0.62
CC
10 (5.3)
11 (5.8)
1.06 (0.43–2.60)
0.90
rs11761231 in female group
7q32
Unknown
T
218 (73.2)
220 (73.8)
1 (reference)
—
TT
79 (53.0)
82 (55.0)
1 (reference)
—
C
80 (26.8)
78 (26.2)
0.97 (0.67–1.39)
0.85
CT
60 (40.3)
56 (37.6)
0.90 (0.56–1.45)
0.66
CC
10 (6.7)
11 (7.4)
1.06 (0.43–2.63)
0.90
rs11761231 in male group
7q32
Unknown
T
69 (86.3)
70 (87.5)
1 (reference)
—
TT
29 (72.5)
30 (75.0)
1 (reference)
—
C
11 (13.7)
10 (12.5)
0.90 (0.36–2.25)
0.82
CT
11 (27.5)
10 (25.0)
1.14 (0.42–3.08)
1.0
CC
0
0
Data shown in (%). OR = odds ratio; 95% CI = 95% confidence interval; MHC: major histocompatibility complex; allele analyses for association were used by Pearson chi-square test, and genotype analyses for association were used by logistic regression.
