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Clinical and Developmental Immunology
Volume 2013, Article ID 906948, 12 pages
http://dx.doi.org/10.1155/2013/906948
Research Article

An Attenuated Cytomegalovirus Vaccine with a Deletion of a Viral Chemokine Gene Is Protective against Congenital CMV Transmission in a Guinea Pig Model

1Department of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, University of Minnesota Medical School, Center for Infectious Diseases and Microbiology Translational Research, 2001 6th Street SE, Minneapolis, MN 55455, USA
2Food and Drug Administration, Regulatory Review Office, Rockville, MD 20852, USA
3Texas A & M Health Sciences Center, Microbial and Molecular Pathogenesis, College Station, TX 77843, USA
4Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN 55455, USA

Received 4 February 2013; Revised 24 May 2013; Accepted 5 June 2013

Academic Editor: Philipp Henneke

Copyright © 2013 Michael P. Leviton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [10 citations]

The following is the list of published articles that have cited the current article.

  • Mark R. Schleiss, Ryan J. Buus, K. Yeon Choi, and Alistair McGregor, “An attenuated CMV vaccine with a deletion in tegument protein GP83 (pp65 homolog) protects against placental infection and improves pregnancy outcome in a Guinea pig challenge model,” Future Virology, vol. 8, no. 12, pp. 1151–1160, 2013. View at Publisher · View at Google Scholar
  • Yiska Weisblum, Amos Panet, Ronit Haimov-Kochman, and Dana G. Wolf, “Models of vertical cytomegalovirus (CMV) transmission and pathogenesis,” Seminars in Immunopathology, 2014. View at Publisher · View at Google Scholar
  • Jinho Heo, Pranay Dogra, Tom J. Masi, Elisabeth A. Pitt, Petra de Kruijf, Martine J. Smit, and Tim E. Sparer, “Novel Human Cytomegalovirus Viral Chemokines, vCXCL-1s, Display Functional Selectivity for Neutrophil Signaling and Function,” Journal Of Immunology, vol. 195, no. 1, pp. 227–236, 2015. View at Publisher · View at Google Scholar
  • Elizabeth C. Swanson, Pete Gillis, Nelmary Hernandez-Alvarado, Claudia Fernández-Alarcón, Megan Schmit, Jason C. Zabeli, Felix Wussow, Don J. Diamond, and Mark R. Schleiss, “Comparison of monovalent glycoprotein B with bivalent gB/pp65 (GP83) vaccine for congenital cytomegalovirus infection in a guinea pig model: Inclusion of GP83 reduces antibody response but provides equivalent protection against mortality,” Vaccine, 2015. View at Publisher · View at Google Scholar
  • Kristy M. Bialas, Takayuki Tanaka, Dollnovan Tran, Valerie Varner, Eduardo Cisneros De La Rosa, Flavia Chiuppesi, Felix Wussow, Lisa Kattenhorn, Sheila Macri, Erika L. Kunz, Judy A. Estroff, Jennifer Kirchherr, Yujuan Yue, Qihua Fan, Michael Lauck, David H. O'Connor, Allison H. S. Hall, Alvarez Xavier, Don J. Diamond, Peter A. Barry, Amitinder Kaur, and Sallie R. Permar, “Maternal CD4(+) T cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus trans,” Proceedings Of The National Academy Of Sciences Of The United States Of America, vol. 112, no. 44, pp. 13645–13650, 2015. View at Publisher · View at Google Scholar
  • Azure N. Faucette, Benjamin L. Unger, Bernard Gonik, and Kang Chen, “Maternal vaccination: moving the science forward,” Human Reproduction Update, vol. 21, no. 1, pp. 119–135, 2015. View at Publisher · View at Google Scholar
  • Mark R. Schleiss, Craig J. Bierle, Elizabeth C. Swanson, Michael A. McVoy, Jian Ben Wang, Zainab Al-Mahdi, and Adam P. Geballe, “Vaccination with a live attenuated cytomegalovirus devoid of a protein kinase R inhibitory gene results in reduced maternal viremia and improved pregnancy outcome in a Guinea pig congenital infection model,” Journal of Virology, vol. 89, no. 19, pp. 9727–9738, 2015. View at Publisher · View at Google Scholar
  • Kristy M. Bialas, and Sallie R. Permar, “The March towards a Vaccine for Congenital CMV: Rationale and Models,” PLoS Pathogens, vol. 12, no. 2, 2016. View at Publisher · View at Google Scholar
  • Nicole L. Davis, Caroline C. King, and Athena P. Kourtis, “Cytomegalovirus infection in pregnancy,” Birth Defects Research, vol. 109, no. 5, pp. 336–346, 2017. View at Publisher · View at Google Scholar
  • Felix Wussow, Flavia Chiuppesi, Heidi Contreras, and Don Diamond, “Neutralization of Human Cytomegalovirus Entry into Fibroblasts and Epithelial Cells,” Vaccines, vol. 5, no. 4, pp. 39, 2017. View at Publisher · View at Google Scholar