The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas

Table 1

MMP overview. It was found that MMP-4, -5, and -6 were identical with MMP-2 or -3. Data compiled from Parks et al. 2004 [17] and Sbardella et al. 2012 [160].

MMP group	MMP subgroup	Designation	Alternative name	Matrix substrate	Bioactive substrate
Simple hemopexin-containing; MMPs	Collagenases	MMP-1	Collagenase-1/ColA/ColB/Fibroblast collagenase/interstitial collagenase	Unclear: Type I and II fibrillar collagens; collagens I, II, III, VII,VIII, X; gelatin; aggrecan; link protein; entactin; tenascin; perlecan	a2-M; a-PI; a1-antichymotrypsin; IGFBP-2, 3, 5; proIL-1b; CTGF
		MMP-8	Neutrophil collagenase	Collagens I, II, III, V, VII, VIII, X; Fn; entactin; tenascin; gelatin; aggrecan; link protein, Mouse CXCL5	a-PI
		MMP-13	Collagenase-3	Collagens I, II, III, IV, VII, IX, X, XIV; aggrecan; gelatin; Fn; tenascin; osteonectin; Ln; perlecan	CTGF; ProTGF-b; MCP-3; a1- antichymotrypsin; plasminogen
	Stromelysins	MMP-3	Stromelysin-1 (transin-1)	E-cadherin, Laminin, type IV collagen, Latent TGF-𝛽1; Aggrecan; decorin; gelatin; Fn; Ln; collagens III, IV, V, IX, X, XI; tenascin; link protein; perlecan; osteonectin; entactin	IGFBP-3; proIL-1b; HB-EGF; CTGF; Ecadherin; a1-antichymotrypsin; a1-PI; a2-M; plasminogen; uPA; pro-MMP-1, 7, 8, 9, 13
		MMP-10	Stromelysin-2	Aggrecan; Ln; Fn; gelatin; collagens III, IV, V, IX, X, XI; tenascin; link protein;	Pro-1, 8, 10
	Others	MMP-12	Macrophage metalloelastase	Latent TNF, Elastin; aggrecan; Fn; collagen IV; gelatin; vitronectin; entactin; osteonectin; Ln; nidogen	Plasminogen; apolipoprotein(a)
		MMP-19	RASI-1	Collagen IV; gelatin; Fn; tenascin; aggrecan; entactin; COMP; Ln; nidogen	IGFBP-3; proIL-1b; HB-EGF; CTGF; E-cadherin; a1-antichymotrypsin; a1-PI; a2-M; plasminogen; uPA; pro-MMP-1, 7, 8, 9, 13
		MMP-20	Enamelysin	Amelogenin; aggrecan; gelatin; COMP	Unknown
		MMP-27	None	Unknown	Unknown
Gelatin-binding; MMPs	Gelatinases	MMP-2	Gelatinase A/72kDa gelatinase	CCL-7/CXCL12, gelatin; collagens I, IV, V, VII, X, XI, XIV; Ln; Fn; elastin;aggrecan; osteonectin; link protein	ProTGF-b; FGF receptor I; MCP-3; IGFBP-5; proIL-1b; galectin-3; plasminogen;
		MMP-9	Gelatinase-B	Zona occludens1, α1-Antiproteinase, latent TGF-β1, latent VEGF, Fibrin, NG2 proteoglycan; gelatin; collagens I, III, IV, V, VII, X, XII; elastin; entactin; aggrecan; Fn; link protein; vitronectin; N-telopeptide of collagen I	ProTGF-b; IL-2 receptor a; Kit-L; IGFBP-3; proIL-1b; ICAM-1; a1-PI; galectin-3; plasminogen
Furin-activated		MMP-11	Stromelysin-3	Fn; Ln; aggrecan; gelatins	a1-PI; a2-M; IGFBP-1
Secreted MMPs		MMP-28	Epilysin	Unknown	Casein
Vitronectin-like insert MMPs		MMP-21	None	Unknown	Unknown
Minimal domain; MMPs	Matrilysins	MMP-7	Matrilysin-1 (Pump-1)	Pro-𝛼-defensins, FAS ligand, latent TNF, syndecan-1, E-cadherin, Elastin; Aggrecan; gelatin; Fn; Ln; elastin; entactin; collagens, III, IV, V, IX, X, XI; tenascin; decorin; link protein; vitronectin	Both lack the hemopexin-line domain, they process collagen IV but not collagen I, Pro a-defensin; Fas-L; b4 integrin; E-cadherin; proTNF-a; CTGF; HB-EGF; RANKL; IGFBP-3; plasminogen
		MMP-26	Matrilysin-2 (endometase)	Gelatin; collagen IV; Fn; fibrinogen; vitronectin	pro-MMP-9; a1-PI
Type I transmembrane; MMPs	MTs-MMPs	MT1-MMP/MMP14		Pro-MMP-2, fibrillar collagens, Fibrin, Syndecan-1, 𝛾1-subunit of laminin-5, collagen I, II, III; gelatin; aggrecan; Fn; Ln; fibrin; vitronectin; entactin; proteoglycans; Ln-5	Pro-MMP-2; Pro-MMP-13; CD44; MCP-3; tissue transglutaminase
		MT2-MMP/MMP-15		Fibrin Fn; tenascin; nidogen; aggrecan; entactin; collagen; gelatin; perlecan; Ln; vitronectin	Pro-MMP-2; tissue transglutaminase
		MT3-MMP/MMP-16		Fibrin, Syndecan-1; collagen III; aggrecan; gelatin; Fn; vitronectin.	Pro-MMP-2; tissue transglutaminase
		MT5-MMP/MMP-24		Gelatin; fibronectin; vitronectin; collagen, aggrecan; PG	Pro-MMP-2
GPI-linked MMPs	MTs-MMPs	MT4-MMP/MMP-17		Gelatin; fibrinogen	Unknown
		MT6-MMP/MMP-25		Gelatin; collagen IV; fibrin; Fn; Ln	ProMMP-2
Type II transmembrane MMPs	MTs-MMPs	MMP-23A	Femalysin	Unknown	Unknown
		MMP-23B		Gelatin	Unknown