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Clinical and Developmental Immunology
Volume 2013, Article ID 915873, 10 pages
http://dx.doi.org/10.1155/2013/915873
Clinical Study

Aberrant T Helper 17 Cells and Related Cytokines in Bone Marrow Microenvironment of Patients with Acute Myeloid Leukemia

1Department of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan 250012, China
2Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan 230001, China
3Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 230001, China

Received 11 March 2013; Revised 4 July 2013; Accepted 10 July 2013

Academic Editor: Samuel Huber

Copyright © 2013 Tian Tian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Löwenberg, J. R. Downing, and A. Burnett, “Acute myeloid leukemia,” The New England Journal of Medicine, vol. 341, no. 14, pp. 1051–1062, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Estey and H. Döhner, “Acute myeloid leukaemia,” The Lancet, vol. 368, no. 9550, pp. 1894–1907, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Fritsche-Polanz, M. Fritz, A. Huber et al., “High frequency of concomitant mastocytosis in patients with acute myeloid leukemia exhibiting the transforming KIT mutation D816V,” Molecular Oncology, vol. 4, no. 4, pp. 335–346, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. A. J. Barrett and K. Le Blanc, “Immunotherapy prospects for acute myeloid leukaemia,” Clinical and Experimental Immunology, vol. 161, no. 2, pp. 223–232, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. P. R. Mangan, L. E. Harrington, D. B. O'Quinn et al., “Transforming growth factor-β induces development of the T H17 lineage,” Nature, vol. 441, no. 7090, pp. 231–234, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. L. E. Harrington, R. D. Hatton, P. R. Mangan et al., “Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages,” Nature Immunology, vol. 6, no. 11, pp. 1123–1132, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Park, Z. Li, X. O. Yang et al., “A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17,” Nature Immunology, vol. 6, no. 11, pp. 1133–1141, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Bettelli, Y. Carrier, W. Gao et al., “Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells,” Nature, vol. 441, no. 7090, pp. 235–238, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Veldhoen, R. J. Hocking, C. J. Atkins, R. M. Locksley, and B. Stockinger, “TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells,” Immunity, vol. 24, no. 2, pp. 179–189, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Lee, A. Awasthi, N. Yosef et al., “Induction and molecular signature of pathogenic TH17 cells,” Nature Immunology, vol. 13, pp. 991–999, 2012. View at Google Scholar
  11. I. I. Ivanov, B. S. McKenzie, L. Zhou et al., “The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells,” Cell, vol. 126, no. 6, pp. 1121–1133, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. M. J. McGeachy and D. J. Cua, “Th17 cell differentiation: the long and winding road,” Immunity, vol. 28, no. 4, pp. 445–453, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Volpe, N. Servant, R. Zollinger et al., “A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses,” Nature Immunology, vol. 9, no. 6, pp. 650–657, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. E. V. Acosta-Rodriguez, G. Napolitani, A. Lanzavecchia, and F. Sallusto, “Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells,” Nature Immunology, vol. 8, no. 9, pp. 942–949, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. D. J. Cua, J. Sherlock, Y. Chen et al., “Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain,” Nature, vol. 421, no. 6924, pp. 744–748, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. C. A. Murphy, C. L. Langrish, Y. Chen et al., “Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation,” Journal of Experimental Medicine, vol. 198, no. 12, pp. 1951–1957, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Hirota, M. Hashimoto, H. Yoshitomi et al., “T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis,” Journal of Experimental Medicine, vol. 204, no. 1, pp. 41–47, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Kebir, K. Kreymborg, I. Ifergan et al., “Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation,” Nature Medicine, vol. 13, no. 10, pp. 1173–1175, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Fitch, E. Harper, I. Skorcheva, S. E. Kurtz, and A. Blauvelt, “Pathophysiology of psoriasis: recent advances on IL-23 and TH17 cytokines,” Current Rheumatology Reports, vol. 9, no. 6, pp. 461–467, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Schmechel, A. Konrad, J. Diegelmann et al., “Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status,” Inflammatory Bowel Diseases, vol. 14, no. 2, pp. 204–212, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Miossec, “Interleukin-17 in fashion, at last: ten years after its description, its cellular source has been identified,” Arthritis and Rheumatism, vol. 56, no. 7, pp. 2111–2115, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Schwarzenberger and J. K. Kolls, “Interleukin 17: an example for gene therapy as a tool to study cytokine mediated regulation of hematopoiesis,” Journal of Cellular Biochemistry, vol. 85, no. 38, pp. 88–95, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. L. A. Tesmer, S. K. Lundy, S. Sarkar, and D. A. Fox, “Th17 cells in human disease,” Immunological Reviews, vol. 223, no. 1, pp. 87–113, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. K. S. Sfanos, T. C. Bruno, C. H. Maris et al., “Phenotypic analysis of prostate-infiltrating lymphocytes reveals T H17 and Treg skewing,” Clinical Cancer Research, vol. 14, no. 11, pp. 3254–3261, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. I. Kryczek, S. Wei, L. Zou et al., “Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment,” Journal of Immunology, vol. 178, no. 11, pp. 6730–6733, 2007. View at Google Scholar · View at Scopus
  26. I. Kryczek, M. Banerjee, P. Cheng et al., “Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments,” Blood, vol. 114, no. 6, pp. 1141–1149, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Zhang, D. Ma, Y. Zhang et al., “The imbalance of Th17/Treg in patients with uterine cervical cancer,” Clinica Chimica Acta, vol. 412, no. 11-12, pp. 894–900, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Wu, S. Wang, F. Wang et al., “Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia,” Clinical and Experimental Immunology, vol. 158, no. 2, pp. 199–204, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. Z. G. Fan, L. S. Zhang, Y. Chai, P. Y. Zeng, and C. Y. Wu, “The prevalence of Th17 cells in patients with acute myeloid leukemia,” Zhonghua Xue Ye Xue Za Zhi, vol. 31, pp. 617–620, 2010. View at Google Scholar
  30. J. M. Bennett, D. Catovsky, M. T. Daniel et al., “Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group,” British Journal of Haematology, vol. 33, pp. 451–458, 1976. View at Google Scholar
  31. B. D. Cheson, P. A. Cassileth, D. R. Head et al., “Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia,” Journal of Clinical Oncology, vol. 8, no. 5, pp. 813–819, 1990. View at Google Scholar · View at Scopus
  32. Y. Hu, H. Li, L. Zhang et al., “Elevated profiles of Th22 cells and correlations with Th17 cells in patients with immune thrombocytopenia,” Human Immunology, vol. 73, pp. 629–635, 2012. View at Google Scholar
  33. T. Maruyama, K. Kono, Y. Mizukami et al., “Distribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer,” Cancer Science, vol. 101, no. 9, pp. 1947–1954, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. L. L. Shao, L. Zhang, Y. Hou et al., “Th22 cells as well as Th17 cells expand differentially in patients with early-stage and late-stage myelodysplastic syndrome,” PLoS ONE, vol. 7, Article ID e51339, 2012. View at Google Scholar
  35. H. Takatori, Y. Kanno, W. T. Watford et al., “Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22,” Journal of Experimental Medicine, vol. 206, no. 1, pp. 35–41, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. L. Yang, D. E. Anderson, C. Baecher-Allan et al., “IL-21 and TGF-β are required for differentiation of human T H17 cells,” Nature, vol. 454, no. 7202, pp. 350–352, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. N. Manel, D. Unutmaz, and D. R. Littman, “The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt,” Nature Immunology, vol. 9, no. 6, pp. 641–649, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. U. Testa, R. Masciulli, E. Tritarelli et al., “Transforming growth factor-β potentiates vitamin D3-induced terminal monocytic differentiation of human leukemic cell lines,” Journal of Immunology, vol. 150, no. 6, pp. 2418–2430, 1993. View at Google Scholar · View at Scopus