Age-Dependent Differences in Systemic and Cell-Autonomous Immunity to L. monocytogenes

Table 1

Age-dependent differences in systemic immunity to L. monocytogenes.

Effector	Role in listeriosis	Neonatal mouse	Neonatal human
Neutrophils	Chemotaxis	?	Decreased
	Extracellular bacteria killing	?	?
Resident tissue macrophages	Production of chemokines	?	?
	Production of TNF𝛼, IL-12p70, IL-18	Reduced IL-12p70	Reduced IL-12p70
Monocytes	Chemotaxis to infection site	Reduced	Reduced
	Differentiation to TipDCs and macrophages	?	?
Dendritic cells (DCs)	Antigen presentation	Reduced	?
	Production of IL-12p70	Reduced	Reduced
−CD8α+ DCs	Bacterial transport to PALS	?	?
−TNF𝛼+ iNOS + DC (TipDC)	Production of TNF𝛼, iNOS	?	?
NK cells	Production of IFN𝛾	?	?
CD4+ T cells	CD8 + Priming	?	?
	Cytokine production	Reduced	Reduced
CD8+ T cells	Bystander production of IFN𝛾	?	?