LPS-Induced Inflammation Potentiates the IL-1𝜷-Mediated Reduction of LH Secretion from the Anterior Pituitary Explants

Table 1

Summary release of LH from the AP explants collected from saline and LPS-treated ewes during the 3 h incubation period.

Group	Concentration of LH (ng/mg)
	Saline treated	LPS treated
Control	15.8 ± 3.6	18.5 ± 5.3
GnRH control	43.5 ± 4.1^a	48.5 ± 4.6^e
IL-1β	14.8 ± 3.2	19.3 ± 4.1
IL-1β + GnRH	31.2 ± 3.0^abc	21.0 ± 3.4^df

^a,b,c,d𝑃≤0.01 (indicating values that differ significantly from the control, GnRH control, IL-1β, and IL-1β + GnRH groups of saline-treated explants, respectively, according to the Mann-Whitney 𝑈-test).
^e,f𝑃≤0.01 (indicating values that differ significantly from the control and GnRH control groups of LPS-treated explants, respectively, according to the Mann-Whitney 𝑈-test).
Data are presented as a median value ± SEM.