The Association of CD81 Polymorphisms with Alloimmunization in Sickle Cell Disease

Table 3

List of genes in the proximity of HBB locus encoding molecules affecting the function of the immune system.

Gene symbol	Distance from HBB locus (MB)	Molecule	Effects on the immune system	Sequence homology
				P. troglodytes	M. musculus	Rattus norvegicus	Canis familiaris
SSA1	0.83	SSA1, Ro52, and TRIM21	Encodes Ro52 antigen in Sjogren Syndrome and lupus [29]	99	69	68	67
ARHG	1.38	RhoG	Stronger immune function in knock-out mice [30]	100	100	100	99
CHRNA10	1.55	𝛼10 subunit of AchR	Modulates T-cell Ca^2+ mobilization [31]	100	91	90	88, 92*
CD81	2.85	CD81	Modulates BCR signaling [32, 33]	99	91	93	83
PHEMX/TSSC6	2.92	TSSC6	Higher T-cell responses in knock-out mice [34]	NA	63	57	NA
LSP1	3.41	LSP1	Regulation of B cell apoptosis [35]	100	67	64	82, 88*
TOLLIP	3.95	Toll inh. prot.	Downmodulates IL-1 and TNF𝛼 signalings [36]	72	93	93	67
CD151	4.39	CD151	Represents blood group antigen MER-2 [37]	98	93	92	94
IRF7	4.60	IRF7	Interferon production [38]	96	62	63	NA
SIGIRR	4.80	SIGIRR	Negative regulator of IL-1 signaling [39]	98	73	82	NA

∗Only partial sequence of canine CHRNA10 and LSP1 genes is available. Distinct numbers represent homology of different available gene segments.