Rapamycin Ameliorates Proteinuria and Restores Nephrin and Podocin Expression in Experimental Membranous Nephropathy

Table 1

Clinical and biochemical characteristics of groups under study.

	Group			𝑃
	PHN	PHN-Rapa	HC	PHN versus PHN-Rapa	PHN versus HC	PHN-Rapa versus HC
Initial body weight (gr)	170 ± 2.8	169 ± 5.2	180 ± 2.1	0.9	0.12	0.1
Final body weight (gr)	335.7 ± 7.3	268.3 ± 12.1	432.5 ± 9.2	<0.001	<0.001	<0.001
Kidney mass (gr)	4.3 ± 0.3	2.8 ± 0.2	4.04 ± 0.02	0.001	0.47	0.009
Kidney mass over body weight	0.013 ± 0.0002	0.010 ± 0.0004	0.009 ± 0.0003	0.013	0.002	0.27
Serum creatinine (mg/dL)	0.30 ± 0.001	0.31 ± 0.03	0.40 ± 0.001	0.55	0.006	0.016
Serum total protein (mg/dL)	5.91 ± 0.14	6.33 ± 0.12	6.77 ± 0.075	0.032	0.001	0.04
Serum albumin (mg/dL)	2.8 ± 0.09	3.1 ± 0.1	3.6 ± 0.04	0.03	0.002	0.04
Serum cholesterol (mg/dL)	187.5 ± 21	313.3 ± 53	66 ± 5	0.03	0.05	0.001