The −174G/C and −572G/C Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis: A Case-Control Study

Table 3

Comparison in genotype and allele frequencies of −174G/C and −572G/C polymorphisms between the groups with rheumatoid arthritis and controls.

Genotype	Polymorphism −174G/C			𝑃	Polymorphism −572G/C			𝑃
	RA; 𝑛 (%); 𝑛=137	Controls; 𝑛 (%); 𝑛=102	OR; (95% CI)		RA; 𝑛 (%); 𝑛=137	Controls; 𝑛 (%); 𝑛=102	OR; (95% CI)
GG	106 (77.4)	80 (78.4)	0.94	0.845	74 (54)	62 (60.8)	0.76	0.295
GC	30 (21.9)	20 (19.6)	(0.48–1.82)		58 (42.3)	37 (36.3)	(0.44–1.32)
CC	1 (0.7)	2 (2)			5 (3.6)	3 (2.9)
Allele
G	242 (88.3)	180 (88.2)	1.01	0.976	206 (75.2)	161 (78.9)	0.81	0.338
C	32 (11.7)	24(11.8)	(0.57–1.8)		68 (24.8)	43 (21.1)	(0.1–1.28)

RA: Rheumatoid arthritis; OR: odds ratio; 95% CI: confidence interval. For genotype, OR was computed using GG as a risk factor and GC + CC as the referent.