T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis

Figure 1

Clinical assessment of CIA and histopathological analysis of joints. The three experimental groups included normal, CIA, and TCV-treated groups. The TCV-treated group was immunized with 1 × 10⁷ irradiated T cells two weeks before the establishment of CIA. The CIA group was injected with PBS as a control. (a) Appearance of relevant paws. (b) Histopathological changes of joints. (HE, left ×100, right ×400). (c) Clinical scores were assessed. Data are represented as means ± SD (𝑛=10 mice/group). Data are representative of 5 separate experiments with similar results. ^$𝑃<0.05, TCV versus CIA group.

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