Research Article
Highlights on Novel Technologies for the Detection of Antibodies to Ro60, Ro52, and SS-B
Table 4
Multiple positivity for Ro60, Ro52, and SS-B.
| | BIO-FLASH | Single positive | Double positive | Triple positive | Ro60 > 110 CU | SS-B > 6.3 CU | SS-B > 482 CU |
| | Sensitivity | 75.9% | 39.8% | 21.3% | 58.3% | 37.0% | 25.0% | | Specificity | 89.5% | 96.2% | 97.7% | 94.7% | 97.0% | 97.0% | | Likelihood ratio (+) | 7.21 | 10.59 | 9.44 | 11.08 | 12.31 | 8.31 | | Likelihood ratio (−) | 0.27 | 0.63 | 0.81 | 0.44 | 0.65 | 0.77 |
| | BioPlex 2200 | Single positive | Double positive | Triple positive | Ro60 > 2.2 units | SS-B > 4.3 units | SS-B > 0.4 units |
| | Sensitivity | 80.6% | 38.9% | 21.3% | 27.8% | 25.0% | 45.4% | | Specificity | 90.2% | 96.2% | 97.0% | 96.2% | 98.5% | 95.5% | | Likelihood ratio (+) | 8.24 | 10.34 | 7.08 | 7.39 | 16.63 | 10.06 | | Likelihood ratio (−) | 0.22 | 0.63 | 0.81 | 0.75 | 0.76 | 0.57 |
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