Research Article
Increased IL-33 in Synovial Fluid and Paired Serum Is Associated with Disease Activity and Autoantibodies in Rheumatoid Arthritis
Table 3
The comparison of clinical features between SF-IL-33-positive and SF-IL-33-negative groups.
| | Measurements | SF-IL-33-positive
() | SF-IL-33-negative
() | Z () | P |
| | Age (yrs) | 49.9 ± 18.5 | 56.0 ± 14.2 | −1.490 | 0.136 | | Gender (M/F) | 11/32 | 12/65 | 1.220 | 0.325 | | Disease duration (yrs) | 10.2 ± 8.9 | 9.0 ± 8.0 | −0.515 | 0.607 | | Tender joint count | 8.1 ± 8.3 | 6.9 ± 7.8 | −0.847 | 0.397 | | Swollen joint count | 8.1 ± 8.0 | 5.4 ± 7.0 | −1.789 | 0.074 | | DAS28 | 5.3 ± 1.2 | 4.7 ± 1.3 | −2.103 | 0.035
*
| | ESR (mm/h) | 66.7 ± 33.0 | 48.7 ± 33.2 | −2.976 | 0.003
*
| | CRP (mg/L) | 49.3 ± 39.4 | 34.9 ± 32.3 | −2.055 | 0.040
*
| | RF-IgM (U/mL) | 440.7 ± 646.0 | 186.8 ± 378.6 | −3.564 | <0.001
*
| | RF-IgG-positive | 46.5% (20) | 27.3% (21) | 3.136 | 0.110 | | GPI-positive | 67.4% (29) | 41.6% (32) | 5.332 | 0.026
*
| | IgA (g/L) | 3.9 ± 1.6 | 3.1 ± 1.4 | −2.258 | 0.024
*
| | IgG (g/L) | 17.1 ± 5.4 | 14.0 ± 4.7 | −2.888 | 0.004
*
| | IgM (g/L) | 1.6 ± 0.8 | 1.2 ± 0.7 | −3.064 | 0.002
*
| | C3 (g/L) | 1.2 ± 0.4 | 1.1 ± 0.3 | −1.002 | 0.317 | | C4 (g/L) | 0.2 ± 0.1 | 0.2 ± 0.1 | −0.077 | 0.939 | | Anti-CCP (RU/mL) | 107.9 ± 80.3 | 97.0 ± 81.6 | −0.937 | 0.349 | | AKA-positive | 21 (48.8%) | 42 (54.5%) | 0.269 | 0.383 | | APF-positive | 25 (58.1%) | 50 (64.9%) | 0.367 | 0.651 |
|
|
P < 0.05.
SF IL-33-positive: SF IL-33 ≥ 23.35 pg/mL; SF IL-33-negative: SF IL-33 < 23.35 pg/mL.
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