Association of TNF-α with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus

Figure 6

TNF-α and IKK-β regulated SLE BMSCs migration through the inhibition of HGF production. (a) Level of HGF mRNA, instead of MMP-2, MMP-9, CXCR4, VEGF, and VCAM-1, was decreased in SLE BMSCs compared with normal BMSCs. (b) HGF expression in SLE BMSCs was downregulated by SLE serum, which was abrogated with the addition of anti-TNF-α mAb. (c) HGF mRNA level in SLE BMSCs pretreated with recombinant human TNF-α with the presence or absence of anti-TNFRI mAb, anti-TNFRII mAb, or TPCA-1 (). TNF50: TNF-α: 50 μg/L; TNF100: TNF-α: 100 μg/L. ; .

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