Dose of Incorporated Immunodominant Antigen in Recombinant BCG Impacts Modestly on Th1 Immune Response and Protective Efficiency against Mycobacterium tuberculosis in Mice

Figure 6

Localization of TNF-α, IFN-γ, and iNOS in infected lungs of mice 5 weeks after infection. Representative photomicrographs show immunohistochemical staining (brown color) for TNF-α (a), IFN-γ (b), and iNOS (c) in pulmonary granulomas (left panel). Quantification of staining (intensity × area of staining) is displayed as mean ± SD. ^∗𝑃<0.05 or ^∗∗𝑃<0.01 (Mann-Whitney 𝑈 test).

(a)

(b)

(c)