Tribbles 3 Regulates the Fibrosis Cytokine TGF-β1 through ERK1/2-MAPK Signaling Pathway in Diabetic Nephropathy

Table 2

Metabolic data of mice in different groups by time.

	16 weeks		20 weeks		25 weeks
	C	DN	C	DN	C	DN
BW (mg)	22.80±2.52	47.86±0.83^∗∗	22.54±1.24	52.26±2.47^∗∗	23.26±0.67	47.52±2.56^∗∗
RBG (mmol/L)	4.48±0.71	12.33±1.67^∗∗	4.78±0.84	24.15±1.62^∗∗△	5.92±0.87	33.08±1.54^∗∗△
UAE (𝜇g/24 h)	27.68±1.65	386.12±16.30^∗∗	24.20±1.45	452.12±32.26^∗∗△	27.24±1.52	551.78±29.19^∗∗△△
BUN (mmol/L)	8.32±0.37	9.38±0.29^∗	8.56±0.43	9.94±0.20^∗∗	8.44±0.45	10.48±0.18^∗∗△
Scr (mmol/L)	14.80±0.58	28.2±1.7	18.00±1.30	33.60±3.37^∗∗	16.60±1.67	25.40±2.77^∗∗

Data are means ± SEM. C: control; DN: diabetic nephropathy; BW: body weight; UAE: urinary albumin excretion; BUN: blood urea nitrogen; Scr: serum creatinine.
^∗𝑃<0.05, ^∗∗𝑃<0.01 versus age-matched control mice.
^△𝑃<0.05, ^△△𝑃<0.01 versus 16-week-old db/db mice.