Journal of Immunology Research / 2014 / Article / Tab 2

Research Article

Long-Lasting Production of New T and B Cells and T-Cell Repertoire Diversity in Patients with Primary Immunodeficiency Who Had Undergone Stem Cell Transplantation: A Single-Centre Experience

Table 2

Multivariable logistic models investigating differences in immune reconstitution between HSCT-SCID and -PID patients.

Outcome and contributing factorsORSE

Probability of having KRECs over the cut-off
 PID1
 SCID0.23000.24210.1630
 Age at transplantation1.01500.01780.3940
 Timea1.07380.01670.0000
 Time × timeb0.99980.00010.0000
Probability of having TRECs over the cut-off
 PID1
 SCID0.48420.35620.3240
 Age at transplantation0.99420.01290.6550
 Time1.04200.00830.0000
 Time × timeb0.99970.00000.0000
Probability of having an unrestricted repertoire 
 PID1
 SCID0.50760.19820.0820
 Age at transplantation0.99400.00690.3870
 Time1.03130.00580.0000
 Time × timeb0.99990.00000.0000

OR: odds ratio; SE: standard error.
HSCT: hematopoietic stem cell transplantation; KRECs: K-deleting recombination excision circles; PID: primary immunodeficiency; SCID: severe combined immunodeficiency; TRECs: T-cell receptor excision circles.
aTime in months since transplantation; it represents the slope of the regression line (see Supplementary Figure  2); bthis factor represents the quadratic term needed to model the curved shape of time patterns, that is, the average monthly rate of change of the slope of the regression line.

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