Journal of Immunology Research / 2014 / Article / Tab 4

Research Article

Long-Lasting Production of New T and B Cells and T-Cell Repertoire Diversity in Patients with Primary Immunodeficiency Who Had Undergone Stem Cell Transplantation: A Single-Centre Experience

Table 4

Multivariable logistic models investigating factors affecting the probability of having an unrestricted repertoire in HSCT patients.

Outcome and contributing factorsORSE

Probability of having an unrestricted repertoire
 Model 1
  TRECs under the cut-off1
  TRECs over the cut-off3.23910.86490.0000
  GvHD × timea1.04030.01190.0010
  GvHD × time × timeb0.99980.00010.0030
 Model 2
  TRECs under the cut-off1
  TRECs over the cut-off2.84690.76160.0000
  GvHD × timea1.10500.03540.0020
  GvHD × time × timeb0.99940.03540.0050
  Ablative conditioning × GvHD × timec0.93050.03290.0420
  Ablative conditioning × GvHD × time × timed1.00050.00020.0260

OR: odds ratio; SE: standard error.
Two models were fitted; reported here are only the significant factors and interactions; predictions of model 2 are depicted in Supplementary Figure  4.
GvHD: graft-versus-host disease.
TRECs: T-cell receptor excision circles.
aTime expressed in months since transplantation; the interaction represents the effect of GvHD on the slope of the regression line (see Supplementary Figure  4); bthis quadratic interaction represents the effect of GvHD on the rate of change of the slope, that is, the curvature of the regression line; c,dthese interactions represent the change of the effect of GvHD on the slope due to the presence or absence of ablative conditioning.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.