Table of Contents Author Guidelines Submit a Manuscript
Journal of Immunology Research
Volume 2014, Article ID 274584, 11 pages
http://dx.doi.org/10.1155/2014/274584
Research Article

HLA-G Expression Is an Independent Predictor for Improved Survival in High Grade Ovarian Carcinomas

1Academic Medical Center, Center of Gynaecologic Oncology, Amsterdam, The Netherlands
2Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
3Free University Medical Center, Center of Gynaecologic Oncology, Amsterdam, The Netherlands

Received 7 January 2014; Accepted 28 March 2014; Published 27 May 2014

Academic Editor: Nathalie Rouas-Freiss

Copyright © 2014 M. J. Rutten et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aberrant expression of human leukocyte antigens (HLA) class I has prognostic importance in various cancers. Here, we evaluated the prognostic value of classical (A/B/C) and nonclassical (G/E) HLA expression in 169 high grade epithelial ovarian cancer samples and linked that to clinicopathological characteristics and survival. Expression of HLA-A, -B/C, or -E was not correlated with survival. Survival was prolonged when tumours expressed HLA-G and HLA-G was an independent predictor for better survival . In addition, HLA-G expression was associated with longer progression-free survival and response to chemotherapy . Accordingly, high expression of HLA-G mRNA was associated with prolonged disease-free survival in 65 corresponding samples. Elevated serum-soluble HLA-G levels as measured by enzyme-linked immunosorbent assay in 50 matched patients were not correlated to HLA-G protein expression or gene expression nor with survival. During treatment, sHLA-G levels declined . In conclusion, expression of HLA-G is an independent prognostic factor for improved survival in high grade epithelial ovarian cancer and a predictor for platinum sensitivity.