Polymorphisms of Tumor Necrosis Factor-α, Transforming Growth Factor-β, and Interleukin-10 in Asthma Associated with Olive Pollen Sensitization

Table 4

Relevant results of TNF- and IL-10 polymorphisms according to Ole e 2 and Ole e 10 sensitization.

Polymorphism	Genotypes	IL-10 levels (pg/mL)	Ole e 2 sensitized; ( = 102)	Ole e 2 nonsensitized; ( = 44)	Ole e 2 asthma; ( = 81)	Asthma; Ole e 2 nonsensitized; ( = 28)	value
			(%)	(%)	(%)	(%)	Ole e 2 sensitized; versus Ole e 2 nonsensitized	Ole e 2 asthma; versus non-Ole e 2 asthma
IL-10-571C>A	CC	7.77 ± 5.4	51 (50)	31 (70.5)	40 (49.4)	22 (78.6)	= 0.029; OR: 0.41; (95% CI 0.19–0.8)	= 0.008; OR: 0.26; (95% CI 0.09–0.7)
	CA	8.76 ± 5.3	45 (44.1)	13 (29.5)	37 (45.7)	6 (21.4)	ns	= 0.02; OR: 3.08; (95% CI: 1.13–8.4)
	AA	5.9 ± 6.1	6 (5.9)	0	4 (4.9)	0	ns	ns
Polymorphism	Genotypes	TNF-α levels (pg/mL)	Ole e 10 sensitized; ( = 79)	Ole e 10 nonsensitized; ( = 67)	Ole e 10 asthma; ( = 66)	Asthma; Ole e 10 nonsensitized; ( = 43)	value
			(%)	(%)	(%)	(%)	Ole e 10 sensitized; versus Ole e 10 nonsensitized	Ole e 10 asthma; versus non-Ole e 10 asthma
TNFA-308G>A	GG	7.01 ± 4.8	59 (74.7)	57 (85.1)	49 (74.2)	36 (83.7)	ns	ns
	GA	7.79 ± 4.5	20 (25.3)	8 (11.9)	17 (25.8)	5 (11.6)	= 0.04; OR: 2.5; (95% CI 1.02–6.1)	ns
	AA	9.3 ± 6.1	0	2 (3)	0	2 (4.7)	ns	ns

Data show only significant results ( < 0.05).