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Journal of Immunology Research
Volume 2014, Article ID 297073, 16 pages
Review Article

HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy

1Institute for Transfusion Medicine, University Hospital Essen, Virchowstraße 179, 45147 Essen, Germany
2CAPES Foundation, Ministry of Education of Brazil, 70.040-020 Brasília, DF, Brazil

Received 14 February 2014; Revised 7 May 2014; Accepted 21 May 2014; Published 21 July 2014

Academic Editor: Marcel Tilanus

Copyright © 2014 Vera Rebmann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


HLA-G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or allograft transplantation, the expression of HLA-G has been related to a better acceptance of the fetus or the allograft. Thus, it seems that HLA-G is crucially involved in mechanisms shaping an allogeneic immune response into tolerance. In this contribution we focus on (i) how HLA-G is involved in transplantation and human reproduction, (ii) how HLA-G is regulated by genetic and microenvironmental factors, and (iii) how HLA-G can offer novel perspectives with respect to therapy.