Review Article
Immunomodulatory Properties of HLA-G in Infectious Diseases
Table 2
Influence of HLA-G polymorphism on susceptibility to infectious diseases.
| Pathogens | Protection | Susceptibility | Vertical transmission (mother-to-child) | References |
| HIV | HLA-G*0105N (null allele) | | | [72, 73] | | G*010108 allele G*010108/010401 G*010101/010108 | | [72] | | G*0105N 14 bp (ins) allele +3142G (insG) haplotype | | [74] [75] [75] | G*01:01:01 genotype | G*01:04:04 genotype | | [122] | | | Differences in the HLA-G gene DNA sequence between mother and child | [76] | | 14 bp insertion allele 14 bp + 3142G (insG) haplotype | | [75] | | insG/insG diplotype in HCV coinfected | | [75] |
| HCV | | insG/insG diplotype in HIV coinfected | | [75] | +3142C allele in sickle cell disease patients | | | [79] | | −14 bp/−14 bp genotype | | [81] | | | | | HLA-G*0105N | | G*010401 homozygosity for HLA-G 14 bp deletion | [80] |
| HPV | 14 bp ins allele | 14 bp del allele del/C haplotype with ICC development | | [82] |
| Plasmodium falciparum | +3187G allele and haplotype UTR1 | Haplotype UTR3 | | [83] | +3010G and +3142C +3010G and +3196G | | | [49] |
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