Review Article

Immunomodulatory Properties of HLA-G in Infectious Diseases

Table 2

Influence of HLA-G polymorphism on susceptibility to infectious diseases.

PathogensProtectionSusceptibilityVertical transmission (mother-to-child)References

HIVHLA-G*0105N
(null allele)
[72, 73]
G*010108 allele
G*010108/010401
G*010101/010108
[72]
G*0105N
14 bp (ins) allele
+3142G (insG) haplotype
[74]
[75]
[75]
G*01:01:01 genotypeG*01:04:04 genotype[122]
Differences in the HLA-G gene DNA sequence between mother and child[76]
14 bp insertion allele
14 bp + 3142G (insG) haplotype
[75]
insG/insG diplotype
in HCV coinfected
[75]

HCVinsG/insG diplotype
in HIV coinfected
[75]
+3142C allele in sickle cell disease patients[79]
−14 bp/−14 bp genotype[81]
HLA-G*0105NG*010401
homozygosity for HLA-G 14 bp deletion
[80]

HPV14 bp ins allele14 bp del allele
del/C haplotype with ICC development
[82]

Plasmodium falciparum +3187G allele
and haplotype UTR1
Haplotype UTR3[83]
+3010G and +3142C
+3010G and +3196G
[49]