Immunomodulatory Properties of HLA-G in Infectious Diseases

Table 3

Interference of viral proteins with HLA-G intracellular trafficking; comparison with classical HLA class I molecules.

Virus	Viral protein	Classical HLA class I		HLA-G			References
		Mechanism	Downregulation	Downregulation	No change	Upregulation
HIV	Nef	Interacts directly with class I domain; Redirects to endolysosomal pathway	↘		→; truncated cytoplasmic domain		[85]
	Vpu	Redirects to degradation pathway; Affects early step in biosynthesis	↘	↘			[119]
HCMV	US2; US11	Exports for cytosolic; degradation	↘		→; truncated cytoplasmic domain		[84, 86]
	US3; US6	Retention in endoplasmic reticulum	↘	↘			[87]
	US10			↘; cytoplasmic tail			[88]
	pp72 and pp86					↗	[99]
Herpes Virus	ICP47	Inhibits TAP (transporter associated with antigen processing)	↘	↘			[90]