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Journal of Immunology Research
Volume 2014, Article ID 301376, 9 pages
http://dx.doi.org/10.1155/2014/301376
Research Article

Gαs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer

Department of Medical Oncology, The First Affiliated Hospital, Xi’an Jiao Tong University of Medical College, Xi’an 710061, China

Received 30 December 2013; Accepted 27 February 2014; Published 31 March 2014

Academic Editor: Jianying Zhang

Copyright © 2014 Lijuan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. la Vecchia, C. Bosetti, F. Lucchini et al., “Cancer mortality in Europe, 2000–2004, and an overview of trends since 1975,” Annals of Oncology, vol. 21, no. 6, pp. 1323–1360, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Jemal, R. Siegel, J. Xu, and E. Ward, “Cancer statistics, 2010,” CA Cancer Journal for Clinicians, vol. 60, no. 5, pp. 277–300, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. H. I. Scher and C. L. Sawyers, “Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis,” Journal of Clinical Oncology, vol. 23, no. 32, pp. 8253–8261, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Mori, Q. Wang, M. L. Quek et al., “Prognostic value of the androgen receptor and its coactivators in patients with D1 prostate cancer,” Anticancer Research B, vol. 28, no. 1, pp. 425–430, 2008. View at Google Scholar · View at Scopus
  5. H. Zhao, M. A. Coram, R. Nolley et al., “Transcript levels of androgen receptor variant AR-V1 or AR-V7 do not predict recurrence in patients with prostate cancer at indeterminate risk for progression,” Journal of Urology, vol. 188, pp. 2158–2164, 2012. View at Google Scholar
  6. K. K. Rasiah, M. Gardiner-Garden, E. J. D. Padilla et al., “HSD17B4 overexpression, an independent biomarker of poor patient outcome in prostate cancer,” Molecular and Cellular Endocrinology, vol. 301, no. 1-2, pp. 89–96, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. G. J. L. H. van Leenders, D. Dukers, D. Hessels et al., “Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features,” European Urology, vol. 52, no. 2, pp. 455–463, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. K. L. Pierce, R. T. Premont, and R. J. Lefkowitz, “Seven-transmembrane receptors,” Nature Reviews Molecular Cell Biology, vol. 3, no. 9, pp. 639–650, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Daaka, “G proteins in cancer: the prostate cancer paradigm,” Science's STKE: Signal Transduction Knowledge Environment, vol. 2004, no. 216, p. re2, 2004. View at Google Scholar · View at Scopus
  10. Y. J. Choi, J. M. Oh, S. Y. Kim, M. Seo, and Y. S. Juhnn, “Stimulatory heterotrimeric GTP-binding protein augments cisplatin-induced apoptosis by upregulating Bak expression in human lung cancer cells,” Cancer Science, vol. 100, no. 6, pp. 1069–1074, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. J. Choi, S. Y. Kim, J. M. Oh, and Y. S. Juhnn, “Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells,” Experimental and Molecular Medicine, vol. 41, no. 8, pp. 592–600, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. E. A. Cho, J. M. Oh, S. Y. Kim, Y. Kim, and Y. S. Juhnn, “Heterotrimeric stimulatory GTP-binding proteins inhibit cisplatin-induced apoptosis by increasing X-linked inhibitor of apoptosis protein expression in cervical cancer cells,” Cancer Science, vol. 102, no. 4, pp. 837–844, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. K. J. Schmitz, H. Langy, U. H. Frey et al., “GNAS1 T393C polymorphism is associated with clinical course in patients with intrahepatic cholangiocarcinoma,” Neoplasia, vol. 9, no. 2, pp. 159–165, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. U. H. Frey, H. Alakus, J. Wohlschlaeger et al., “GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer,” Clinical Cancer Research, vol. 11, no. 14, pp. 5071–5077, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. U. H. Frey, H. Nückel, L. Sellmann et al., “The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia,” Clinical Cancer Research, vol. 12, no. 19, pp. 5686–5692, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. U. H. Frey, G. Lümmen, T. Jäger et al., “The GNAS1 T393C polymorphism predicts survival in patients with clear cell renal cell carcinoma,” Clinical Cancer Research I, vol. 12, no. 3, pp. 759–763, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Eisenhardt, A. Scherag, K. H. Jöckel, H. Reis, H. Rübben, and W. Siffert, “Lack of association of the genotype in the GNAS fok i polymorphism and prostate cancer,” Urologia Internationalis, vol. 87, no. 1, pp. 80–86, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Watanabe, Y. Hirokawa, M. Tsuji et al., “Lack of involvement of the GNAS1 T393C polymorphism in prostate cancer risk in a Japanese population,” Anticancer Research A, vol. 28, no. 6, pp. 3711–3716, 2008. View at Google Scholar · View at Scopus
  19. J. Liu, H. Youn, J. Yang et al., “G-protein alpha-s and -12 subunits are involved in androgen-stimulated PI3K activation and androgen receptor transactivation in prostate cancer cells,” Prostate, vol. 71, no. 12, pp. 1276–1286, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. M. O. García-Fernández, R. M. Solano, M. Sánchez-Chapado, A. Ruiz-Villaespesa, J. C. Prieto, and M. J. Carmena, “Low expression of gα protein subunits in human prostate cancer,” Journal of Urology, vol. 166, no. 6, pp. 2512–2517, 2001. View at Google Scholar · View at Scopus
  21. V. Tischler, F. R. Fritzsche, P. J. Wild et al., “Periostin is up-regulated in high grade and high stage prostate cancer,” BMC Cancer, vol. 10, article 273, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. H. R. Bourne, D. A. Sanders, and F. McCormick, “The GTPase superfamily: a conserved switch for diverse cell functions,” Nature, vol. 348, no. 6297, pp. 125–132, 1990. View at Publisher · View at Google Scholar · View at Scopus
  23. M. I. Simon, M. P. Strathmann, and N. Gautam, “Diversity of G proteins in signal transduction,” Science, vol. 252, no. 5007, pp. 802–808, 1991. View at Google Scholar · View at Scopus
  24. Y. Yarden and M. X. Sliwkowski, “Untangling the ErbB signalling network,” Nature Reviews Molecular Cell Biology, vol. 2, no. 2, pp. 127–137, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. E. R. Sherwood and C. Lee, “Epidermal growth factor-related peptides and the epidermal growth factor receptor in normal and malignant prostate,” World Journal of Urology, vol. 13, no. 5, pp. 290–296, 1995. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. S. Pu, M. W. Hsieh, C. W. Wang et al., “Epidermal growth factor receptor inhibitor (PD168393) potentiates cytotoxic effects of paclitaxel against androgen-independent prostate cancer cells,” Biochemical Pharmacology, vol. 71, no. 6, pp. 751–760, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Kharait, R. Dhir, D. Lauffenburger, and A. Wells, “Protein kinase Cδ signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells,” Biochemical and Biophysical Research Communications, vol. 343, no. 3, pp. 848–856, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. T. Zellweger, C. Ninck, M. Bloch et al., “Expression patterns of potential therapeutic targets in prostate cancer,” International Journal of Cancer, vol. 113, no. 4, pp. 619–628, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. E. Hernes, F. Fosså, A. Berner, B. Otnes, and J. M. Nesland, “Expression of the epidermal growth factor receptor family in prostate carcinoma before and during androgen-independence,” British Journal of Cancer, vol. 90, no. 2, pp. 449–454, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. G. di Lorenzo, G. Tortora, F. P. D'Armiento et al., “Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer,” Clinical Cancer Research, vol. 8, no. 11, pp. 3438–3444, 2002. View at Google Scholar · View at Scopus
  31. D. C. Weber, J. C. Tille, C. Combescure et al., “The prognostic value of expression of HIF1alpha, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy,” Radiation Oncology, vol. 7, p. 66, 2012. View at Google Scholar
  32. A. M. Traish and A. Morgentaler, “Epidermal growth factor receptor expression escapes androgen regulation in prostate cancer: a potential molecular switch for tumour growth,” British Journal of Cancer, vol. 101, no. 12, pp. 1949–1956, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. E. R. Sherwood, J. L. van Dongen, C. G. Wood, S. Liao, J. M. Kozlowski, and C. Lee, “Epidermal growth factor receptor activation in androgen-independent but not androgen-stimulated growth of human prostatic carcinoma cells,” British Journal of Cancer, vol. 77, no. 6, pp. 855–861, 1998. View at Google Scholar · View at Scopus
  34. S. Xu and Z. Weihua, “Loss of EGFR induced autophagy sensitizes hormone refractory prostate cancer cells to adriamycin,” Prostate, vol. 71, no. 11, pp. 1216–1224, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. B. Zheng, C. Lavoie, T. D. Tang et al., “Regulation of epidermal growth factor receptor degradation by heterotrimeric Gαs protein,” Molecular Biology of the Cell, vol. 15, no. 12, pp. 5538–5550, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. A. O. Beas, V. Taupin, C. Teodorof, L. T. Nguyen, and M. Garcia-Marcos, “Galphas promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin),” Molecular Biology of the Cell, vol. 23, pp. 4623–4634, 2012. View at Google Scholar