Research Article
Gαs Protein Expression Is an Independent Predictor of Recurrence in Prostate Cancer
Table 2
Characterization of the cohort of 347 prostate cancer samples.
| Variable | Number | Gαs positive | Gαs negative | | |
| All patients | 347 | 160 | 187 | | |
| Age at diagnosis (years) | | | | | | ≤73 | 211 | 96 | 115 | 0.081 | 0.826 | >74 | 136 | 64 | 72 | Clinical stage at diagnosis | | | | | | I | 49 | 31 | 18 | 9.358 | <0.001* | II | 125 | 61 | 64 | III | 117 | 51 | 66 | IV | 56 | 17 | 39 | Gleason score at diagnosis | | | | | | 2–6 | 145 | 83 | 62 | 15.692 | <0.001* | 7 | 127 | 54 | 73 | 8–10 | 75 | 23 | 52 | Preoperative PSA (ng/mL) | | | | | | <35 | 184 | 99 | 85 | 9.334 | 0.003* | ≥35 | 163 | 61 | 102 | Angiolymphatic invasion | | | | | | Presence | 114 | 48 | 66 | 1.096 | 0.350 | Absence | 233 | 112 | 121 | Extraprostatic extension | | | | | | Presence | 105 | 53 | 52 | 0.993 | 0.351 | Absence | 242 | 135 | 107 | Positive surgical margin | | | | | | Presence | 128 | 60 | 68 | 0.048 | 0.911 | Absence | 219 | 100 | 119 | Seminal vesicle invasion | | | | | | Presence | 172 | 78 | 94 | 0.079 | 0.830 | Absence | 175 | 82 | 93 | Positive lymph node | | | | | | Presence | 34 | 14 | 20 | 0.369 | 0.590 | Absence | 313 | 146 | 167 | PSA progression | | | | | | Presence | 213 | 89 | 124 | 4.153 | 0.047* | Absence | 134 | 71 | 63 |
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Significant differences of Gαs expression among different clinical factors groups in prostate cancer samples.
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